Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorVanderbilt University Medical Center
About this trial
The purpose of this study is to see how stress influences the effects of opioid pain medications often used to help relieve back pain. The study will help to learn more about how high stress levels could increase risk for pain medication misuse.
Eligibility criteria
Qualifiers
Intact cognitive status and ability to provide informed consent
Ability to read and write in English sufficiently to understand and complete study questionnaires (which are only validated in English)
Age 18 or older And
Presence of persistent daily low back pain of at least three months duration and of at least a 3/10 in average intensity
Disqualifiers
History of renal or hepatic dysfunction
Reports of current or past alcohol or substance abuse or treatment for such condition
A reported history of PTSD, psychotic, or bipolar disorders
Chronic pain due to malignancy (e.g., cancer) or autoimmune disorders (e.g., rheumatoid arthritis, lupus)
Trial design
Treatments tested in this trial
- Placebo
- Oxycodone
- Naloxone
Treatment groups
120 Participants
are divided into 1 treatment groupSponsors and collaborators
Vanderbilt University Medical Center
Lead sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov