About this trial
Decompressive hemicraniectomy (DC) is the standard procedure and life saving measure in case of malignant middle cerebral artery (MCA) infarction. However, there have been several studies reporting the neuroinflammatory cascade based on the necrotic tissue as one of the leading cause for the secondary brain damage, wherefore, strokectomy with resection of necrotic tissue has been proposed in some case series as an alternative surgical option. Thus, the aim of this study is to perform a pilot study by including patients with malignant MCA infarction and to check the feasibility of this specific surgical treatment.
Eligibility criteria
Qualifiers
18 years of age or older
Ischemic middle cerebral artery (MCA) infarction at least two thirds of the MCA territory
Clinical symptoms of acute unilateral MCA infarction less than 48 hours prior to the initiation of treatment
Disqualifiers
Preexisting modified Rankin Scale >2
Absence of pupillary reflexes or GCS <6
Intracerebral hemorrhage or other associated brain lesions
Contraindications for surgery
Trial design
Treatments tested in this trial
- Strokectomy/Necrosectomy