Strokectomy in Malignant Cerebral Media Infarction

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Rostock

About this trial

Decompressive hemicraniectomy (DC) is the standard procedure and life saving measure in case of malignant middle cerebral artery (MCA) infarction. However, there have been several studies reporting the neuroinflammatory cascade based on the necrotic tissue as one of the leading cause for the secondary brain damage, wherefore, strokectomy with resection of necrotic tissue has been proposed in some case series as an alternative surgical option. Thus, the aim of this study is to perform a pilot study by including patients with malignant MCA infarction and to check the feasibility of this specific surgical treatment.

Eligibility criteria

Qualifiers

18 years of age or older

Ischemic middle cerebral artery (MCA) infarction at least two thirds of the MCA territory

Clinical symptoms of acute unilateral MCA infarction less than 48 hours prior to the initiation of treatment

Disqualifiers

Preexisting modified Rankin Scale >2

Absence of pupillary reflexes or GCS <6

Intracerebral hemorrhage or other associated brain lesions

Contraindications for surgery

Trial design

Treatments tested in this trial

  • Strokectomy/Necrosectomy

Treatment groups

10 Participants
are divided into 1 treatment group

Sponsors and collaborators