Structure and Function MRI of Asthma
ConditionAsthma
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorDr. Grace Parraga
About this trial
The investigators will apply 129Xenon and/or 3He image acquisition and analysis methods in 200 asthma patient volunteers in order to characterize and probe the relationship between lung structure and function using imaging.
Eligibility criteria
Qualifiers
Subjects male and female aged 18-60 with a clinical diagnosis of asthma
Smoking history ≤ 1 pack/year
Subject understands the study procedures and is willing to participate in the study as indicated by signature on the informed consent
Subject is judged to be in otherwise stable health on the basis of medical history
Disqualifiers
Patient is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material
Patient is unable to perform spirometry or plethysmography maneuvers
Subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants.) (At the discretion of the MRI Technologist/3T Manager)
In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia.
Trial design
Treatments tested in this trial
- Hyperpolarized Noble Gas MRI
Treatment groups
200 Participants
are divided into 1 treatment groupSponsors and collaborators
Dr. Grace Parraga
Lead sponsor
Western University, Canada
Sponsor institution
Source ClinicalTrials.gov