Study Comparing Two Administration Pathways for Adenosine During Microvascular Function Assessment
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorJohannes Gutenberg University Mainz
About this trial
The aim of this study is to investigate the agreement and reproducibility between intravenous and intracoronary adenosine administration during invasive assessment of microvascular function.
Goals of this study are:
1. Agreement and reproducibility between intravenous and intracoronary adenosine administration in the IMR (Index of microvascular resistance) value. 2. Agreement and reproducibility of FFR(fractional flow reserve), CFR (coronary flow reserve), MRR (microvascular resistance reserve), RRR (resistive reserve ratio) and reproducibility of each of these as compared with CFRabs (absolute coronary flow). 3. Time required for IMR measurements
Eligibility criteria
Qualifiers
Chronic coronary syndrome (including patients with anginal equivalents).
Indication to cardiac catheterization;
Indication to the assessment of microvascular function (note: patients will be asked for participation and consented prior to the first measurement of microvascular function, which will be conducted as per clinical indication)
Willingness to participate and ability to understand, read and sign the informed consent
Disqualifiers
Age <18 years
Bronchial asthma, COPD (chronic obstructive pulmonary disease)
Secondary or tertiary atrioventricular block without prior pacemaker implantation
Previous CABG (coronary artery bypass graft) with patent grafts to the left anterior descending coronary
Trial design
Treatments tested in this trial
- microvascular function assessment
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov