Study of Brain-Gut Function Reconstruction After Intersphincteric Resection for Ultra-Low Rectal Tumors

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorHuashan Hospital

About this trial

To investigate the effects of intersphincteric resection (ISR) of ultra-low rectal tumor on the brain-rectoanal function of patients, and to precisely localize the cerebral functional regulatory regions for intervention targets of anorectal remodeling. Utilizing transcranial magnetic stimulation(TMS) technology to explore the functional remodeling of the "new" anorectal muscle groups and provide a theoretical basis for more research on the rehabilitation and mechanism of fecal incontinence.

Eligibility criteria

Qualifiers

Primary ultra-low rectal tumor patient who is received intersphincteric resection and preventive ileostomy was performed.

Patient who is willing to participate in the study, and voluntarily sign informed consent.

Disqualifiers

Anastomotic leakage or other serious complications occur after surgery.

Advanced tumor, tumor recurrence or metastasis.

Patients with contraindications of fMRI scanning, such as history of metal implants in the body, claustrophobia, etc.

Patients with contraindications for TMS treatment, such as intracranial metal implants, epilepsy history, heart disease with unstable heart function, retinal detachment, etc.

Trial design

Treatments tested in this trial

  • Transcranial magnetic stimulation
  • Sham Transcranial magnetic stimulationt

Treatment groups

57 Participants
are divided into 3 treatment groups

Sponsors and collaborators