Study of Cellular Heterogeneity in Patients With Mastocytosis
ConditionMastocytosis
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Hospital, Toulouse
About this trial
This study will aim to study the heterogeneity of skin-resident mast cells and of blood circulating hematopoietic progenitors in patients suffering from isolated Cutaneous Mastocytosis and from systemic Mastocytosis with skin lesions.
Eligibility criteria
Qualifiers
Subject affiliated with a social security or insurance scheme
Subject who has given written consent to his participation in the study
Subject diagnosed with isolated cutaneous or indolent systemic mastocytosis with associated skin involvement defined according to World Health Organization criteria (and/or international criteria for cutaneous mastocytosis)
Subjects whose KIT mutation status is known in the skin, bone marrow, and blood
Disqualifiers
Sun exposure of the biopsied areas expected within the 4 weeks preceding
Subjects who have had exposure to sunlight or artificial UV radiation within the 2 weeks preceding inclusion at the biopsied areas
Adult patients under legal protection, guardianship, or curatorship
Pregnant or lactating women
Trial design
Treatments tested in this trial
- scRNAseq
- two Skin biopsies
- one Skin biopsies
Treatment groups
26 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov