Study design: It is a monocentric and exploratory study, experimental on human tissues in vitro which involves the analysis of peripheral blood in patients with Hodgkin's lymphomas with the following characteristics:
* in complete remission for at least two years after first-line therapy with stage IIb, III or IV at onset (Ann Arbor classification). * newly diagnosed (stage IIb, III or IV, Ann Arbor Classification).
hodgkin lymphoma stage II b, III or IV at onset in remission for at least two years after the first line of therapy for lymphoma
Newly diagnosed histologically confirmed stage II b, III or IV patients who require first-line therapy
Patients of both sexes aged ≥ 18 years at enrollment
Signature of informed consent
Concomitant second neoplasm