This project anchors osteoporotic fractures, conduct registration and follow-up studies, and conduct prospective treatment studies. By registering for follow-up studies on osteoporotic fractures, it is planned to obtain epidemiological data through registration and follow-up studies; A prospective treatment study for patients with osteoporotic fractures is planned to explore effective treatment strategies through randomized controlled trials; To study biomarkers for osteoporotic refractures, we plan to establish a biomarker warning model through multi omics research; To study imaging biomarkers for osteoporotic refractures, a new imaging technology is proposed to establish an imaging omics warning model.
New brittle hip fractures;
New brittle vertebral fractures;
New other site fractures and/or total hip or neck of femur or L1-L4 T-value < -1.0;
Men or postmenopausal women;
bone metabolic diseases except for osteoporosis eg. a. (Osteogenesis Imperfecta, Paget's disease, Osteomalacia), b. Cushing's syndrome, c.hyperprolactinemia;
Having primary hyperparathyroidism or hypothyroidism;
Had or have osteomyelitis of the jaw or necrosis of the jaw;
GFR<30ml/min/1.73m2;