Study of the Nasal Intracellular Reservoir of Staphylococcus Aureus in Patients With S. Aureus Bacteremia

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire de Saint Etienne

About this trial

Staphylococcus aureus bacteremia is a serious infection associated with a high mortality rate (with or without associated infective endocarditis (IE)), long hospital stays and multiple complications, due to the terrain in which it occurs and its secondary localization. They may be community-acquired or healthcare-associated infections. Being a carrier of S. aureus is a known risk factor for S. aureus bacteremia. Although several mucosal sites of carriage have been described, screening for carriage is most often carried out at the nasal level, both for reasons of simplicity and because it is the predominant site of carriage of this bacterium. However, S. aureus carriage is a frequent occurrence, affecting around 1/3 of the general population.

Eligibility criteria

Qualifiers

Bacteremia

Patient affiliated or entitled to a social security plan

Patient who has signed a consent form to participate in the study.

Disqualifiers

Antibiotic therapy in place for more than 5 days at the time of inclusion

Nasal decolonization of S. aureus within 12 months

Pregnant or breast-feeding women

Patients under guardianship

Trial design

Treatments tested in this trial

  • Nasal swab
  • Venous sampling
  • Antibiotic treatment
  • Nasal swab
  • Intracellular reservoir test

Treatment groups

405 Participants
are divided into 2 treatment groups