Study on the Efficacy of Temporal Interference Stimulation (TIS) for Parkinson's Disease
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorZhongnan Hospital
About this trial
The primary objective of this clinical study is to evaluate the therapeutic efficacy of Temporal Interference Stimulation (TIS), a non-invasive deep brain stimulation technique, in patients with Parkinson's disease, and to further investigate its potential mechanisms of action. Although TIS offers lower stimulation intensity and precision compared to conventional Deep Brain Stimulation (DBS), it possesses the distinct advantage of being non-invasive. This study utilizes TIS to explore different stimulation targets analogous to those used in DBS for Parkinson's disease, thereby providing valuable insights for subsequent DBS surgical interventions. The findings will contribute preliminary exploratory evidence regarding the application of non-invasive deep brain stimulation technology in the treatment of Parkinson's disease.
Eligibility criteria
Qualifiers
Adult males or females aged 40 years or above;
Diagnosed with idiopathic Parkinson's disease according to the UK Brain Bank Criteria, with onset after 40 years of age;
Previous or current dopaminergic replacement therapy (e.g., levodopa) with good response; (4) Hoehn and Yahr (H&Y) stage 1.5-2.5;
Ability to walk independently without assistive devices for at least 5 minutes;
Disqualifiers
Presence of other neurological disorders that may interfere with the study
Mild or greater cognitive impairment (MoCA score ≤23)
Orthopedic or other health conditions that may affect gait or balance
Contraindications to MRI scanning, such as claustrophobia
Trial design
Treatments tested in this trial
- TIS
Treatment groups
24 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
Source ClinicalTrials.gov