Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorQifu Li

About this trial

To evaluate the incidence of adrenal insufficiency after surgery in Primary aldosteronism (PA) patients concurrent with or without autonomous cortisol secretion (ACS). To assess the recovery time of postoperative adrenal insufficiency in patients. And to explore the clinical characteristics and predictive indicators of patients requiring postoperative hormone replacement therapy.

Eligibility criteria

Qualifiers

A confirmed diagnosis of primary aldosteronism or autonomous cortisol secretion;

Disqualifiers

Patients with typical clinical manifestations of Cushing's syndrome;

Patients suspected of having bilateral cortisol over-secretion, such as PBMAH or PPNAD; ③ Patients with severe surgical complications, unstable postoperative condition (not due to cortical insufficiency), and difficulty completing the ACTH stimulation test;

History of ACTH allergy;

Patients requiring long-term hormone therapy for other diseases (such as autoimmune diseases);

Trial design

Treatments tested in this trial

  • complete ACTH stimulation test the day after surgery and complete ACTH stimulation test 1 or 4 week for patients with Adrenal Insufficiency

Treatment groups

521 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Qifu Li

Lead sponsor

Chongqing Medical University

Sponsor institution