About this trial
To evaluate the incidence of adrenal insufficiency after surgery in Primary aldosteronism (PA) patients concurrent with or without autonomous cortisol secretion (ACS). To assess the recovery time of postoperative adrenal insufficiency in patients. And to explore the clinical characteristics and predictive indicators of patients requiring postoperative hormone replacement therapy.
Eligibility criteria
Qualifiers
A confirmed diagnosis of primary aldosteronism or autonomous cortisol secretion;
Disqualifiers
Patients with typical clinical manifestations of Cushing's syndrome;
Patients suspected of having bilateral cortisol over-secretion, such as PBMAH or PPNAD; ③ Patients with severe surgical complications, unstable postoperative condition (not due to cortical insufficiency), and difficulty completing the ACTH stimulation test;
History of ACTH allergy;
Patients requiring long-term hormone therapy for other diseases (such as autoimmune diseases);
Trial design
Treatments tested in this trial
- complete ACTH stimulation test the day after surgery and complete ACTH stimulation test 1 or 4 week for patients with Adrenal Insufficiency
Treatment groups
Sponsors and collaborators
Qifu Li
Lead sponsor
Chongqing Medical University
Sponsor institution