Study to Detect Dendritic Cell Recruitment in Human Retina
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age55-80
SponsorMindImmune Therapeutics, Inc.
About this trial
The goal of this study is to develop an optimal method to detect the immune cells (cells that protect the human body against diseases) in association with abnormal conditions of the retina (light sensitive tissue in the back of the eye) that will be relevant to diseases such as age related macular degeneration (AMD), mild cognitive impairment (MCI) due to Alzheimer's Disease (AD) or mild AD.
The main objectives of this study are:
1. Establish Optimal Method for Retinal Imaging of Dendritic Cells (DCs) 2. Safety and Tolerability of ICG infusion in normal healthy, older adult volunteers, in participants with AMD (Dry AMD with Geographic Atrophy (GA)), and in participants who have received a diagnosis of either Mild Cognitive Impairment (MCI) due to AD, or mild AD
Eligibility criteria
Qualifiers
All Study Participants
Male or female and between the ages of 55 to 80 years old (inclusive)
Participants are determined by the qualified investigator to be medically stable and able to understand and agree to comply with the study procedures and report for scheduled study visits.
Participants have adequate hearing, vision, and language skills to provide informed consent and to cooperate with all retinal imaging, cognitive testing, interviews and other medical procedures as specified in the protocol. Hearing augmentation (i.e., hearing aids) are allowed.
Disqualifiers
Medical History
Participants with a history of any anaphylactic reactions to drugs
Participants with a history of allergic reaction to ICG
Participants with a history of iodine sensitivity and/or allergic reaction to iodine
Trial design
Treatments tested in this trial
- Not listed
Trial groups
15 Participants
are grouped into 3 trial groupsLocations
Sponsors and collaborators
MindImmune Therapeutics, Inc.
Lead sponsor
Syneos Health
Collaborator
CHU de Quebec-Universite Laval
Collaborator
Source ClinicalTrials.gov