Health Trials

Substance P-Induced Migraine Attacks Without Aura

ConditionMigraine
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorDanish Headache Center

About this trial

Substance P is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether its administration can trigger migraine attacks in individuals with migraine without aura.

Eligibility criteria

Qualifiers

Age 18 to 65 years of age upon entry into screening

A body weight of 50 to 100 kg

History of migraine without aura for ≥12 months and in accordance with ICHD-3

Between 1-5 monthly migraine days without aura on average across the 3 months prior to screening

Disqualifiers

Any history of a primary or secondary headache disorder other than migraine without aura and infrequent episodic tension-type headache

Any history of moderate to severe traumatic brain injury

Any history of cardiovascular disease, including cerebrovascular diseases

Any history of pulmonary disease

Trial design

Treatments tested in this trial

  • Substance P
  • Placebo

Treatment groups

21 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Danish Headache Center

Lead sponsor

Rigshospitalet, Denmark

Sponsor institution

Source ClinicalTrials.gov