Suicide Specific Rumination in Veterans
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorVA Office of Research and Development
About this trial
Few treatments target core features of suicidal thoughts and behaviors in Veterans. Real-time functional magnetic resonance imaging neurofeedback can provide information regarding brain activation associated with suicide-specific rumination, defined as a "repetitive mental fixation on one's suicidal thoughts and intentions." The goal of this feasibility study is for Veterans to learn strategies for modulating activity within brain regions that have been demonstrated to contribute to the maintenance of rumination, as they receive neurofeedback feedback signals from the brain.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
U.S. military veteran between 18-65 years old
negative pregnancy test on MRI scan days
score greater than or equal to 10 on the Suicide Rumination Scale
clinically stabilized on psychotropic medications
Disqualifiers
no major medical or neurological disorders that could interfere with treatment
moderate or severe traumatic brain injury
current imminent suicide risk, as determined through psychiatric interview, responses to C-SSRS, and clinical judgment of the assessor
any current psychotic disorder
Trial design
Design model
Single group
Treatments tested in this trial
Real Time fMRI Neurofeedback
BehavioralThe proposed pilot study is designed to collect feasibility and acceptability data regarding the utility of real-time functional magnetic resonance imaging (rt-fMRI) feedback in reducing suicide-specific rumination in veterans. Fifteen veterans will receive 2 rt-fMRI neurofeedback sessions while attempting to alter connectivity in brain regions that play a role in rumination. Pre- and post-treatment assessments of suicide, disability, functional impairment, and quality of life will be collected.
Treatment groups
15 Participants
are divided into 1 treatment groupGroup A: Real-time fMRI NeurofeedbackExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Acceptability and Feasibility
The Client Satisfaction Questionnaire will be used to assess acceptability and feasibility of implementing real-time fMRI neurofeedback in a Veteran population. The total score on the questionnaire ranges from from 8 to 32 with higher scores indicative of greater satisfaction.
Time frame
Total score obtained 2 weeks following first real-time fMRI neurofeedback session.Secondary outcomes
1
Suicide Rumination Scale
The Suicide Rumination Scale is a self-report inventory designed to quantify the extent to which an individual ruminates about suicide. The total score on the scale ranges from 0 to 32 with higher scores indicative of greater rumination.
Time frame
Change in total score from pre-treatment to post-treatment (2 weeks).Sponsors and contacts
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Source ClinicalTrials.gov