Super-Resolution Ultrasound of the Brain in 3D
ConditionCerebral Stroke
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAssistance Publique - Hôpitaux de Paris
About this trial
The goal of this proof of concept study is to determine if the visualization of the middle cerebral artery and its perforators, through 3D transtemporal ultrasound imaging, is possible thanks to an off-line analysis by 3D ultrasound localization microscopy. Visualization of these vessels would allow us to conclude on the presence, or absence, of an ischemic stroke in the region of the middle cerebral artery.
To answer the question asked, 20 participants who suffered a stroke will carry out a transtemporal ultrasound examination specifically for research in the 7 days following his stroke. The data obtained will be analyzed by the CNRS medical imaging laboratory, in order to characterize the presence of a stroke and to compare the data obtained with that of standard examinations (CT and MRI).
Eligibility criteria
Qualifiers
Patient aged 18 and over
Hospitalized patient with ischemic stroke in the deep territory of the middle cerebral artery
Patient with lesion observable on MRI
Patient included between 24 hours and 7 days after the ischemic stroke
Disqualifiers
Contralateral middle cerebral artery territory stroke or contralateral middle cerebral artery occlusion
Patient with contraindication to Doppler ultrasound with contrast (right-left shunt, severe pulmonary arterial hypertension)
Patient with hypersensitivity to the active princip of Sonovue (sulfur hexafluoride) or these excipients
Patient with uncontrolled systemic hypertension
Trial design
Treatments tested in this trial
- Transtemporal ultrasound with contrast product (Sonovue)
Treatment groups
20 Participants
are divided into 1 treatment groupSponsors and collaborators
Assistance Publique - Hôpitaux de Paris
Lead sponsor
Centre National de la Recherche Scientifique, France
Collaborator
Source ClinicalTrials.gov