Supplement and Exercise Effects on Stationary Immunity and Health in Older Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorUniversity of Valencia
About this trial
The goal of this clinical trial is to learn whether a natural-origin nutritional supplement, combined with a moderate-intensity functional exercise program, can improve seasonal immunity, perceived health, and oxidative stress in older adults. The study will also assess the safety of this combined intervention.
The main questions it aims to answer are:
* Does the combination of supplementation and exercise enhance immune function during seasonal changes? * Does it reduce oxidative stress and improve perceived health and functional capacity?
Researchers will compare a supplement to a placebo. All participants will follow the same supervised functional exercise program.
Participants will:
* Take a daily nutritional supplement for 6 months. * Attend two weekly functional exercise sessions (60 minutes each), including mobility, explosive strength, and coordination/agility training. * Complete three assessments (before, midway, and after the intervention) including blood tests, physical function evaluations, and quality of life questionnaires.
Eligibility criteria
Qualifiers
Adults aged 65 years or older
Functional independence, defined as the ability to perform activities of daily living without assistance
Sufficient cognitive capacity to understand instructions and complete questionnaires, assessed through interview or brief cognitive screening if necessary
Not immunosuppressed
Disqualifiers
Active autoimmune diseases or clinically relevant immunosuppression
Use of corticosteroids or immunosuppressive drugs in the 4 weeks prior to study initiation
Active infection or compatible symptoms (fever, cough, diarrhea) in the 2 weeks prior to any measurement
Unstable cardiovascular conditions or medical contraindications for moderate physical exercise
Trial design
Treatments tested in this trial
- Group 1: Exercise + nutritional supplement (EXNS)
- Group 2: Exercise + placebo nutritional supplement (EXPlaNS)
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov