The investigators carried out a multi-center comparative study, involving hospitals including the Second Affiliated Hospital of Zhejiang University School of Medicine, Peking Union Medical College Hospital, West China Hospital, Wenzhou First Hospital, and Li Huili Hospital. This study aimed to compare the efficacy of medication and surgery for specific subtypes of microadenomas and clearly defined macroadenomas (Knosp grades 0-2), in order to determine which is more effective and which has fewer benefits, thereby enhancing the evidence base.
Prolactin level greater than three times the normal upper limit
MRI indicates Knosp Grade 0-2 pituitary adenoma
MRI indicates Knosp grade 3-4 pituitary adenoma
Taking antidepressants or other psychotropic drugs
Patients allergic to bromocriptine or cannot tolerate surgery
Women defined as surgical infertility (i.e. hysterectomy, bilateral salpingectomy, or bilateral oophorectomy), or amenorrhea for more than 2 years
Second Affiliated Hospital, School of Medicine, Zhejiang University
Lead sponsor
Peking Union Medical College Hospital
Collaborator
West China Hospital
Collaborator
First Affiliated Hospital of Wenzhou Medical University
Collaborator
Ningbo Medical Center Lihuili Hospital
Collaborator