This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease. The study evaluates differences in survival, major cardiovascular events, and quality of life over 4 years, and contributes to the international STICH 3.0 collaboration assessing long-term outcomes.
Age ≥ 18 years
LVEF≤ 40%
Angina pectoris, CCS≥2 and/or hospitalization for ACS or heart failure within 1 year prior to randomization
Multivessel CAD (2-3 vessel-disease with coronary lesions >70% and involvement of proximal LAD, and/or LM stenosis of >50%). Target vessels are determined by the local Heart Time
ACS < 48 hours before randomization
Valvular/structural heart disease requiring intervention
Contra-indications to DAPT
Non-cardiac condition with life expectancy < 1 year
University Medical Center Groningen
Lead sponsor
Dutch Heart Foundation
Collaborator