About this trial
Improvement in pediatric intensive care unit (PICU) supportive care has led to improvement in clinical outcomes and decreased mortality in pediatric critical illness. However, PICU survivors are at risk of long-term health sequalae. Given the increased recognition of physical, cognitive, and psychological sequelae in PICU survivors, the concept of post-intensive care syndrome-pediatrics (PICS-p) has been proposed. Besides the PICU patient/survivor, the PICS-p framework also highlights the impacts of a child's critical illness has on the family. The impact of a PICU admission extends beyond the patient and parents, potentially affecting healthy siblings who are navigating their own developmental challenges. Healthy siblings may face emotional distress, increased responsibilities, and disruptions in their daily routines, all of which can contribute to long-term negative outcomes if unaddressed. Thus, this study consists of two cohorts to understand the long-term physical, cognitive, and psychological outcomes in PICU survivors and their families, and the short-term impacts on siblings of critically ill children.
Eligibility criteria
Qualifiers
Between 28 days - 16 years of age at PICU admission
Have an expected PICU stay > 48 hours*
Healthy children (aged 4 -16 years old) with critically ill sibling between 28 days - 16 years of age at PICU admission
Has a critically ill sibling who has an expected PICU stay > 48 hours
Disqualifiers
Do-Not-Resuscitate status
Lack of informed consent
Prior enrolment in this study
Children of critically ill sibling with Do-Not-Resuscitate status
Trial design
Treatments tested in this trial
- This is a non-interventional study.
Treatment groups
Sponsors and collaborators
KK Women's and Children's Hospital
Lead sponsor
National University Hospital, Singapore
Collaborator
Duke-NUS Graduate Medical School
Collaborator
Singapore Clinical Research Institute
Collaborator