SweetSpot - The Effect of Non-nutritive Sweeteners on Health
ConditionHealthy Adult
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-79
SponsorWageningen University
About this trial
The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and preference, and the excretion of NNS in urine.
Eligibility criteria
Qualifiers
Age 45-79 years;
BMI of 20-35 kg/m2;
Having veins suitable for placement of a venflon catheter.
Disqualifiers
Diseases or prior surgeries affecting the stomach, liver, kidneys or intestines (allowed i.e. appendectomy);
Cardiovascular diseases (e.g. heart failure) or cancer (e.g. non-invasive skin cancer allowed);
Diagnosed with type 1 or type 2 diabetes;
Drug treated thyroid diseases (well substituted hypothyroidism is allowed for inclusion);
Trial design
Treatments tested in this trial
- Diet with non-nutritive sweeteners
- Diet without non-nutritive sweeteners
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Wageningen University
Lead sponsor
Food & Biobased Research - Wageningen UR
Collaborator
TKI Agri & Food
Collaborator
The Magnum Ice Cream Company
Collaborator
Tate & Lyle
Collaborator
Symrise AG
Collaborator
American Beverage Association
Collaborator
Yildiz Holding
Collaborator
Source ClinicalTrials.gov