Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel Imaging
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Edinburgh
About this trial
The goal of this observational study is to characterise the relationships between inflammation, microcalcification and thrombus activity in atherosclerotic plaques in peripheral and systemic vascular territories in patients with symptomatic peripheral arterial disease.
Eligibility criteria
Qualifiers
Male or female aged > 18 years
Symptomatic atherosclerotic peripheral artery disease;
Intermittent claudication; with ankle/arm blood pressure ratio <0.90 or artery stenosis >50% in addition to at least one of the following;
>1 vascular bed affected by atherosclerosis
Disqualifiers
Contraindication to colchicine or iodinated contrast
Long term requirement for colchicine for another clinical indication
Active diarrhoea
Recent lower limb revascularisation for symptomatic disease (<6 weeks)
Trial design
Treatments tested in this trial
- Whole body [68Ga]DOTATATE PET-CT
- Whole body [18F]GP1 PET-CT
- Whole body [18F]NaF PET-CT
- Whole body CT angiogram
Treatment groups
100 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Edinburgh
Lead sponsor
NHS Lothian
Collaborator
Source ClinicalTrials.gov