About this trial
Nausea and vomiting are common GI symptoms of pregnancy. Multiple managing options have been used for NVP. Doxylamine succinate is used as first line treatment for NVP despite that alternative modalities such as ginger extracts and tablets is being explored.
This RCT will be conducted after taking ethical approval and informed consent, in Department of Gynecology, Aziz Bhatti Shaheed teaching hospital, Gujrat. Patients will be divided into two equal groups. One group will receive tablet ginger while other group will receive Doxylamine succinate tablets. Baseline PUQE score (3- 15 point scale) over 24 hour will be noted according to symptoms of nausea and vomiting following 7 days of treatment and then at 2nd and 3rd week. Comparison of the change in the severity of nausea from baseline scores (Post-therapy PUQE score - base line scores) in both groups will be considered for results.
Eligibility criteria
Qualifiers
Pregnant women age>18 years
5 to 8weeks of gestation and 8+1to11weeks
Attending OPD with signs and symptoms of nausea and vomiting with ultrasound confirmed pregnancy
1st and 2nd gravida
Disqualifiers
Patients were hospitalized for Hyperemesis Gravidarum
Medical disorders like Diabetes Mellitus, Hepatic, Gastric, Pancreatic, Pyelonephritis, Thyroid and Psychological Disorder
Patients not responding to treatment after 1week will be excluded
Patients who will not give consent
Trial design
Treatments tested in this trial
- Doxylamine Succinate USP
- Ginger
Treatment groups
Sponsors and collaborators
Nawaz Sharif Medical College
Lead sponsor
University of Gujrat
Collaborator