Tapering Heart Failure Medication in Patients With Heart Failure With Recovered Ejection Fraction; Open Label Prospective Random Trial

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorChungnam National University Hospital

About this trial

Study start date is on Nov 27th 2024.

A patient with an initial ejection fraction (EF) of less than 40%, whose follow-up shows an improvement to an EF of 50% or higher, along with the left ventricular end-diastolic diameter returning to the normal range and taking 3 more heart failure medication randomed to drug tapering group ( RAS blocker or beta blocker) or continuing medication group.

Eligibility criteria

Qualifiers

initial echocardiogram ejection fraction less than 40%

follow up echocardiogram ejection fraction over 50% and LVEDD index normal range

NTprobnp criteria

eGFR ≥60 ; less 440

Disqualifiers

under age 18 year

uncontrolled BP ( over 150/90)

coronary revascularization within 6 months

significant valve disease

Trial design

Treatments tested in this trial

  • RAS blocker tapering group
  • Beta blocker tapering out

Treatment groups

150 Participants
are divided into 3 treatment groups