About this trial
This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.
Eligibility criteria
Qualifiers
Ability to understand and follow instructions.
Diagnosis of Multiple Sclerosis according to McDonald criteria.
Expanded Disability Status Scale (EDSS) between 1 and 6.
Stable condition in the last three months.
Disqualifiers
Peripheral neurological injury of lower limbs.
Metal objects in the head.
Uncontrolled epilepsy.
Diagnosis of psychiatric disorder.
Trial design
Treatments tested in this trial
- tDCS
- shamtDCS
Treatment groups
Sponsors and collaborators
University of Castilla-La Mancha
Lead sponsor
Asociación Esclerosis Múltiple de Toledo, España
Collaborator