tDCS for Late-Life Depression
ConditionLate Life Depression (LLD)
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorAndre Russowsky Brunoni
About this trial
The purpose of this research study is to determine the effectiveness of Transcranial direct current stimulation (tDCS) therapy in the treatment of participants with Late-life depression (LLD).
The study will evaluate feasibility, safety, and tolerability of high-dose (6mA) bilateral tDCS delivered as three daily sessions, 3 times a week, for 3 weeks in older adults (60 y/o and older) with late-life depression.
Eligibility criteria
Qualifiers
age 60 years or older;
diagnosis of unipolar major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by the Mini International Neuropsychiatric Interview (MINI);
score of 17 or higher on the 17-item Hamilton Depression Rating Scale (HDRS-17) at screening;
stable antidepressant regimen for at least four weeks prior to enrollment, if applicable;
Disqualifiers
contraindications to tDCS including metallic cranial implants, skin conditions at electrode sites (eczema, open wounds, burns, lesions), or history of adverse reaction to tDCS;
contraindications to magnetic resonance imaging (MRI) including pacemaker, cochlear implants, ferromagnetic implants, or claustrophobia;
history of seizures or epilepsy;
bipolar disorder, psychotic disorders, or severe personality disorder;
Trial design
Treatments tested in this trial
- High-intensity (6 mA) transcranial direct current stimulation (tDCS)
Treatment groups
20 Participants
are divided into 1 treatment groupSponsors and collaborators
Andre Russowsky Brunoni
Lead sponsor
University of Texas Southwestern Medical Center
Sponsor institution
Source ClinicalTrials.gov