TDCS Interventions for Subthreshold Depressive Symptoms in Young Individuals.
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age12-25
SponsorGuangzhou Psychiatric Hospital
About this trial
The purpose of this study is to assess the mechanisms of the effect of transcranial direct current stimulation (tDCS) in alleviating subthreshold depressive symptoms in young individuals, and individualized outcome prediction is carried out.
Eligibility criteria
Qualifiers
1) Be between the ages of 12-25;
2) is right-handed on the Edinburgh Handedness Inventory;
3) 2-4 of the 9 depressive symptoms defined by the American Diagnostic and Statistical Manual of Diseases, Fifth Edition (DSM-5), lasting more than 1 week; or more than 5 depressive symptoms lasting more than 1 week but less than 2 weeks (i.e., not meeting criteria for a major depressive episode) (by DSM-5 Clinical Semi-Definitive Interview (K-SADS-PL) (Gilbody et al., 2017, JAMA);
4) Hamilton Depression Scale (HAMD-24) 24 points≥ 8 points, < 24 points;
Disqualifiers
1) Individuals with the following diagnoses according to DSM-5: psychiatric disorders due to organic diseases, substance-related and addictive disorders, neurodevelopmental disorders, schizophrenia spectrum and other psychotic disorders, bipolar disorder (assessed by K-SADS-PL);
2) Have two or more DSM-V-defined manic symptoms for 4 days but do not meet the criteria for hypomania or meet the DSM-V defined criteria for hypomanic symptoms for only 2-3 days;
3) Severe or unstable physical illness;
4) have a moderate or higher risk of suicide (as assessed by the Columbia Suicide Severity Scale);
Trial design
Treatments tested in this trial
- tdcs lDLPFC
- tdcs rVLPFC
- Sham
Treatment groups
150 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov