Testing an Accelerated TMS Protocol for Methamphetamine Use Disorder
ConditionMethamphetamine Use Disorder
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-65
SponsorUniversity of Colorado, Denver
About this trial
The investigators will evaluate the effects of an accelerated Transcranial Magnetic Stimulation (TMS) protocol of the left dorsolateral prefrontal cortex (DLPFC) for moderate to severe methamphetamine use disorder. This is a randomized parallel group design to assess feasibility and safety, evaluate efficacy (use, craving) and identify magnetic resonance imaging (resting state and cue craving) associated with group/outcomes.
Eligibility criteria
Qualifiers
Age 21-65 years inclusive;
Meets DSM-5 criteria for past-year moderate or severe methamphetamine use disorder;
By Timeline Follow Back endorses at least 10 days of methamphetamine use out of the last month;
Provides a urine drug screen positive for methamphetamine;
Disqualifiers
Lifetime non-substance-induced psychotic disorders, schizophrenia, schizoaffective disorder or bipolar disorder defined by DSM-5;
Current diagnosis of DSM-5 drug use disorder other than stimulant, cannabis or nicotine use disorder;
Non-substance-induced manic episode within the past 3 years or major depressive episode in the past year;
Current clinically significant neurological disorder or medical illness, including history of seizures, cardiovascular disease/cardiac event, which in the opinion of the study physician would make study participation unsafe;
Trial design
Treatments tested in this trial
- Sham TMS
- Active TMS
Treatment groups
20 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Colorado, Denver
Lead sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov