The A D A G I O Study
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-90
SponsorGuy's and St Thomas' NHS Foundation Trust
About this trial
This study aims to investigate the effect of different types of glaucoma surgery on aqueous dynamics parameters (IOP, aqueous flow rate, trabecular outflow facility and uveoscleral outflow) in patients with uncontrolled open angle glaucoma or ocular hypertension (OHT)
Eligibility criteria
Qualifiers
Males or females between the ages of 18 and 90 (inclusive).
Able to understand the study and give informed consent.
Willing, able and available to participate in the study. If Flurophotometer test required must not have had prior cataract surgery.
Diagnosis of glaucoma or OHT which requires glaucoma surgery (trans-trabecular meshwork surgery with or without an implant, trans-scleral surgery with or without implant, ciliary body treatment, suprachoroidal surgery with or without implant, external non-incisional treatment). (Defined as primary or secondary glaucoma; all types of secondary glaucoma may be included. Glaucoma will be diagnosed based on abnormal visual field testing and corresponding disc changes once seen by a glaucoma specialist.)
Disqualifiers
Diagnostic criteria for inclusion not met.
Allergy to fluorescein.
It is judged as not clinically safe or patient is not willing to undergo treatment washout (stop taking glaucoma drops).
Current use of any investigational drug or device or current participation in an interventional clinical trial/study.
Trial design
Treatments tested in this trial
- Glaucoma Surgery
Treatment groups
150 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
Source ClinicalTrials.gov