The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorPeking University Third Hospital
About this trial
The goal of this study is to quantitatively assess renal microcirculation changes by contrast-enhanced ultrasound and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore its predictive value in renal function recovery in patients with critical acute kidney injury. The main questions it aims to answer are:
1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation. 2. To explore the relationship between renal microcirculation and systemic hemodynamics. 3. To explore the value of renal microflow changes quantitatively evaluated by contrast-enhanced ultrasound in predicting renal function recovery.
Eligibility criteria
Qualifiers
Age >18 years old;
AKI was diagnosed < 24 hours after first admission to intensive care unit (ICU) and the expected length of stay in ICU ≥48 hours;
Meet Kidney Disease Improving Global Outcomes (KDIGO) 2012 diagnostic criteria for acute kidney injury;
Contrast-enhanced ultrasound was performed within 24 hours after diagnosis of acute kidney injury (AKI).
Disqualifiers
Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment;
Kidney transplantation or renal malignancy;
Terminal stage of malignant tumor;
Pregnancy;
Trial design
Treatments tested in this trial
- Renal microcirculation quantitatively assessed by Contrast-enhanced ultrasound
Treatment groups
44 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov