The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke

ConditionAcute Stroke
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-86
SponsorInsel Gruppe AG, University Hospital Bern

About this trial

Acute ischemic stroke is caused by blockage of blood vessels in the brain. Blood vessels can be obstructed by several different mechanisms and identification of this cause is essential to minimize the risk of recurrence.

Eligibility criteria

Qualifiers

Informed consent as documented by signature.

Age: ≥ 18 and < 86 years.

Acute ischemic stroke with symptom onset within 12 hours before admission to hospital.

Diagnosis of acute ischemic stroke with MRI with diffusion restriction as seen on diffusion weighted imaging.

Disqualifiers

Pregnancy. A negative pregnancy test upon admission is required for all women with child-bearing potential.

Standard contraindication for performing MRI.

Severe renal failure (GFR <40).

Trial design

Treatments tested in this trial

  • Short cardiovascular MRI (CMR)
  • Adenosine-perfusion cardiovascular MRI (CMR)
  • Blood draw
  • Urine (collection over 24h)

Treatment groups

220 Participants
are divided into 4 treatment groups