The Cardiovascular Impact of Hot Flushes

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age40-70
SponsorUniversity of Minnesota

About this trial

The overall objective of this study is to examine the physiological responses that occur during a hot flush in postmenopausal women. The following specific aims will be executed to reach the overall objective of this study. Aim 1: To determine if hot flushes can be reliably induced with a temperature-controlled, water- circulating (TCWC) heating pad. Based on previous research, the investigators hypothesize that hot flushes will be inducible with the TCWC in symptomatic women, but not in asymptomatic women. Aim 2: To determine if heat-induced hot flushes in symptomatic women will cause reproducible cardiovascular and respiratory responses. The investigators hypothesize that heat-induced hot flushes produce similar and reproducible cardiovascular and respiratory responses to spontaneous hot flushes. Aim 3: To determine if body fat percentage influences hot flush severity or frequency during spontaneous or induced hot flushes. The investigators hypothesize that women with higher body fat have reduced hot flash severity and frequency.

Eligibility criteria

Qualifiers

Postmenopausal (may have or may not have hot flushes)

Have not started hormone therapy and/or will discontinue hormone therapy for the duration of the study

Disqualifiers

Reported nicotine/tobacco use within the last six months

Diabetic or asthmatic

Diagnosed significant carotid stenosis

History of significant autonomic dysfunction, heart disease, respiratory disease, or severe neurologic condition such as stroke or traumatic brain injury

Trial design

Treatments tested in this trial

  • Hot Flush Induction

Treatment groups

60 Participants
are divided into 2 treatment groups

Sponsors and collaborators