The Chinese Familial Alzheimer's Network
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCapital Medical University
About this trial
This research will establish and continuously improve the FAD research network in conjunction with multi-center institutions nationwide. By collecting information on the family's demography, genetics, neuropsychology, neuroimaging, biomarkers and other information, we can understand the current FAD population in China, clarify the genetic characteristics, pathogenesis, disease characteristics and diagnosis and treatment status of AD in China; which will lay the foundation for ameliorating clinical diagnosis and treatment, establishing a Chinese FAD clinical database and an international cooperative research platform.
1. To set up a multi-center, nationwide FAD research network and database platform in China 2. To clarify the epidemiological characteristics of FAD in China. 3. To clarify the genetic characteristics of FAD in China. 4. To clarify the clinical characteristics and disease development laws of FAD. 5. To discover and verify the early diagnosis biomarkers of AD. 6. To establish a genetic counseling model.
Eligibility criteria
Qualifiers
Written informed consent obtained from the participant or a legal guardian prior to any study-related procedures;
At least two first-degree relatives in a family have AD (clinically or by testing)，and at least 3 out of 2 generations are patients;
At least one family member with normal cognitive function (the age should be greater than the average age of onset of the family);
Pedigrees carrying FAD pathogenic genes (APP/PSEN1/PSEN2);
Disqualifiers
Dementia caused by other factors such as depression, other psychiatric illnesses, thyroid dysfunction, encephalitis, multiple sclerosis, brain trauma, brain tumor, syphilis, acquired immunodeficiency syndrome (AIDS), Creutzfeldt-Jakob disease and other types of dementias such as vascular dementia (VaD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and Parkinson's dementia (PDD)；
MRI and laboratory tests do not support or rule out a diagnosis of AD；
Severe circulatory, respiratory, urinary, digestive, hematopoietic diseases (such as unstable angina, uncontrollable asthma, active gastric bleeding) and cancer；
Participant has severe psychiatric illness or severe dementia that would interfere in completing initial and follow-up clinical assessments；
Trial design
Treatments tested in this trial
- Not listed
Trial groups
40,000 Participants
are grouped into 2 trial groupsSponsors and collaborators
Capital Medical University
Lead sponsor
Beijing Tiantan Hospital
Collaborator
Beijing Chao Yang Hospital
Collaborator
Fu Xing Hospital, Capital Medical University
Collaborator
Peking Union Medical College Hospital
Collaborator
Peking University First Hospital
Collaborator
Peking University Third Hospital
Collaborator
Chinese PLA General Hospital
Collaborator
China-Japan Friendship Hospital
Collaborator
Beijing Geriatric Hospital
Collaborator
The First Affiliated Hospital of Dalian Medical University
Collaborator
Fujian Medical University Union Hospital
Collaborator
Guangzhou Psychiatric Hospital
Collaborator
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Collaborator
First Affiliated Hospital of Guangxi Medical University
Collaborator
The Affiliated Hospital Of Guizhou Medical University
Collaborator
Handan Central Hospital
Collaborator
Hebei General Hospital
Collaborator
First Hospital of Shijiazhuang City
Collaborator
Tangshan Worker's Hospital
Collaborator
Henan Provincial People's Hospital
Collaborator
Kaifeng Central Hospital
Collaborator
People's Hospital of Zhengzhou University
Collaborator
First Affiliated Hospital of Harbin Medical University
Collaborator
Tongji Hospital
Collaborator
People's Hospital Affiliated Hubei Medical University
Collaborator
Zhongnan Hospital
Collaborator
The Third Xiangya Hospital of Central South University
Collaborator
Xiangya Hospital of Central South University
Collaborator
The First Hospital of Jilin University
Collaborator
China-Japan Union Hospital, Jilin University
Collaborator
Subei People's Hospital of Jiangsu
Collaborator
Nantong University Affiliated Hospital
Collaborator
Mineral General Hospital, Xuzhou
Collaborator
Jiangxi Provincial People's Hopital
Collaborator
Anshan Central Hospital
Collaborator
Affiliated Zhongshan Hospital of Dalian University
Collaborator
First Hospital of China Medical University
Collaborator
Baotou Central Hospital
Collaborator
General Hospital of Ningxia Medical University
Collaborator
The People's Hospital of Ningxia
Collaborator
The Affiliated Hospital of Qingdao University
Collaborator
The 960th Hospital of PLA
Collaborator
Qilu Hospital of Shandong University
Collaborator
Qilu Hospital of Shandong University (Qingdao)
Collaborator
Shandong Provincial Hospital
Collaborator
Qingdao Municipal Hospital
Collaborator
The First Affiliated Hospital of Shanxi Medical University
Collaborator
Tang-Du Hospital
Collaborator
First Affiliated Hospital Xi'an Jiaotong University
Collaborator
Ruijin Hospital
Collaborator
RenJi Hospital
Collaborator
Shanghai Changzheng Hospital
Collaborator
Affiliated Hospital of North Sichuan Medical College
Collaborator
Tianjin Huanhu Hospital
Collaborator
Tianjin Medical University General Hospital
Collaborator
Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region
Collaborator
Ningbo Medical Center Lihuili Hospital
Collaborator
First Affiliated Hospital of Wenzhou Medical University
Collaborator
First Affiliated Hospital of Zhejiang University
Collaborator
Shao Yifu Hospital of Zhejiang Medical University
Collaborator
Zhejiang Provincial People's Hospital
Collaborator
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Collaborator
The Second Affiliated Hospital of Chongqing Medical University
Collaborator
The First Affiliated Hospital of Anhui Medical University
Collaborator
People's Hospital of Chongqing
Collaborator
Dongfang Hospital Beijing University of Chinese Medicine
Collaborator
Zigong No.1 Peoples Hospital
Collaborator
Source ClinicalTrials.gov