The Choice of Treatment Methods and Efficacy of LABC
ConditionLocally Advanced Breast Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-70
SponsorPeking Union Medical College Hospital
About this trial
The goal of this clinical trial is to compare the therapeutic effects of chemotherapy followed by surgery and surgery followed by chemotherapy in patients with locally advanced breast cancer（LABC). Patients with LABC will be randomly divided into two groups, each receiving chemotherapy followed by surgery or surgery followed by chemotherapy. The main comparison was between the disease-free survival (DFS) of two groups of patients, with the secondary study endpoint being overall survival (OS); Five year survival; Local recurrence or distant metastasis rate.
Eligibility criteria
Qualifiers
18-70 year old female
Patients with locally advanced breast cancer (stage IIIb - IIIc) first diagnosed;
Clinical diagnosis of breast cancer, or puncture pathology suggests breast cancer;
After evaluation by experienced clinical physicians, the patient's tumor has the possibility of surgical resection. Specific evaluation indicators include ultrasound assessment of the tumor not surrounding the axillary vein;
Disqualifiers
Patients under 18 years old or over 70 years old;
Those who have received breast cancer related surgery, radiotherapy or chemotherapy;
Those who are not expected to receive surgery, radiotherapy or chemotherapy related to breast cancer
History of other malignant tumors;
Trial design
Treatments tested in this trial
- Modified radical mastectomy for breast cancer
- neoadjuvant therapy
- Systematic treatment
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov