The aim of this study is to compare the effects of 16 weeks of daily dietary supplementation with two investigational products containing collagen, methylsulfonylmethane (MSM), and vitamin C on skin parameters in comparison to a placebo product. The study will be conducted in healthy human subjects with visible facial erythema and telangiectasiae (cheeks), stable for ≥3 months, without active rosacea.
The primary objective is to demonstrate beneficial effects of the investigational products on facial erythema.
The secondary objective is to evaluate the effect of the investigational products on facial telangiectasiae severity.
Other skin parameters will be assessed as supportive endpoints, and differences in efficacy between the two investigational formulations will also be evaluated.
Caucasian female volunteers aged 35 to 65 years at the time of signing the Informed Consent Form (ICF).
Signed Informed Consent Form (ICF).
Fitzpatrick skin phototypes I-IV.
Presence of visible signs of skin ageing.
Pregnancy or breastfeeding.
Vegan diet.
Heavy smoking or frequent alcohol-induced flushing.
Occupational or hobby-related excessive heat exposure (e.g. chefs, sauna workers) likely to interfere with vascular stability.
VIST - Faculty of Applied Sciences
Lead sponsor
Tosla d.o.o.
Collaborator
Slovenian Research Agency
Collaborator