To explore the effect of a single intravenous injection of esketamine during cesarean section on postoperative pruritus in patients with intrahepatic cholestasis of pregnancy.
Age: 18 - 40 years old; Gestational age: ≥ 35 weeks; Singleton pregnancy.
Clear consciousness, able to cooperate with NRS scoring, laboratory tests and follow-up.
Meet the diagnostic criteria of the "Clinical Diagnosis, Treatment and Management Guidelines for Intrahepatic Cholestasis of Pregnancy (2024 Edition)" : fasting serum TBA≥10 μmol/L or postprandial serum TBA≥19 μmol/L.
Reporting pruritus NRS ≥ 4 points twice within one week.
Those who are known to be allergic to the drug components or have an allergic constitution.
Related to the safe use of esketamine: history of mental illness; uncontrolled hypertension; uncontrolled hyperthyroidism; increased intracranial pressure, increased intraocular pressure; long-term alcohol consumption or drug abuse history.
Those with severe organic diseases and liver diseases.
Those with malignant tumors.