The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-70
SponsorGerman Diabetes Center
About this trial
The purpose of this study is:
1. To explore to what extent insulin sensitivity, energy metabolism and ectopic lipid storage can be improved by bariatric surgery 2. To explore to what extent hepatic and muscular disorders of energy metabolism occur in patients with obesity (degree 2-3) 3. To explore whether the steato liver occurring in patients with obesity (degree 2-3) is associated with the degree of liver inflammation
Eligibility criteria
Qualifiers
Aged ≥ 20 years- ≤ 70 years
BMI 20- 25 kg/m 2 normal- weight group
BMI 35- 39,9 kg/m 2 (Obesity grade 2)
BMI >40 kg/m 2 (Obesity grade 3)
Disqualifiers
Acute illness 2 weeks before start of examination
Autoimmune or Immune disorder diseases (Leukozyten < 5000/µl
Renal insufficiency (Kreatin > 1,5 mg/dl)
Heart disease, condition after heart attack
Trial design
Treatments tested in this trial
- surgery
Treatment groups
450 Participants
are divided into 1 treatment groupSponsors and collaborators
German Diabetes Center
Lead sponsor
Dep.of General-, Visceral- and Pediatric Surgery, HHU, Duesseldorf, Germany
Collaborator
Dep.for Metabolic Diseases, HHU, Duesseldorf, Germany
Collaborator
Hospital Neuwerk, Mönchengladbach, Duesseldorf, Germany
Collaborator
Source ClinicalTrials.gov