The goal of this clinical trial is to investigate the effect of continuous versus intermittent enteral nutrition on metabolic outcomes in critically ill adult patients.
The aim of this study is to:
• To assess the effect of a daytime intermittent tube feeding pattern compared to standard continuous tube feeding on glycaemic control, gastrointestinal function, gastrointestinal hormones, markers of sleep quality and circadian rhythm, and lean body mass and body composition.
Participants will receive either continuous enteral nutrition for 24 hours a day or intermittent enteral nutrition during the day, consisting of 4 portions each administered over 1 hour between 8 am and 8 pm. The maximum duration of the intervention is 5 days or until participants do not receive exclusive gastric enteral nutrition.
Age ≥18 years;
Receiving or eligible to receive exclusively gastric tube feeding;
Expected ICU stay ≥48 hours;
Receiving or anticipated to receive invasive mechanical ventilation within 48 hours after ICU admission.
The treating clinician considers participation in the study clinically contraindicated (e.g., change in feeding regimen, no possibility for placement of CGM on arms, not able to receive exclusive gastric tube feeding);
Death is deemed to be imminent or inevitable during admission, and the attending doctor, patient, or substitute decision-maker is not committed to active treatment;
Pregnancy;
Expected fasting for ≥12 hours during the study period, for example, due to medical procedures;
Gelderse Vallei Hospital
Lead sponsor
ZonMw: The Netherlands Organisation for Health Research and Development
Collaborator
Wageningen University and Research
Collaborator