The Effect of Dual Task Training on Cognitive in Alzheimer's Disease
ConditionAlzheimer Disease
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorFenerbahce University
About this trial
This randomized controlled clinical trial aims to evaluate the effectiveness of dual-task training on cognitive functions in patients with Alzheimer's disease. Participants will be randomly assigned to either a dual-task training group or a conventional exercise group. The intervention will last 8 weeks, with three supervised sessions per week. Cognitive performance, mobility, balance, and quality of life will be assessed before and after the intervention.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥ 60 years
Diagnosed with mild-stage Alzheimer's disease (According to DSM-5 or NINCDS-ADRDA criteria)
MoCA score between 10-25 (Indicating sufficient cognitive capacity for dual-task training)
Ability to walk independently or with minimal assistance
Disqualifiers
Diagnosis of advanced-stage Alzheimer's disease (MoCA < 10)
Presence of additional neurological disorders affecting the motor system (e.g. Parkinson's disease, stroke, multiple sclerosis)
Severe hearing or vision impairment (inability to respond to visual or auditory stimuli)
History of psychiatric disorders (e.g., major depression, schizophrenia)
Trial design
Design model
Parallel
Treatments tested in this trial
Dual-Task Motor-Cognitive Training
Other interventionParticipants assigned to this group will undergo dual-task motor-cognitive training, which combines physical exercises with simultaneous cognitive tasks. Sessions will last 45-60 minutes, three times per week, for 8 weeks. Exercises will include gait and balance activities performed while engaging in cognitive tasks such as arithmetic, memory recall, or word association.
Conventional Exercise Training
Other interventionParticipants in this group will receive a conventional exercise program focusing on strength, flexibility, and balance without a cognitive component. Sessions will last 45-60 minutes, three times per week, for 8 weeks, and will be supervised by a physiotherapist.
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: Dual-task motor-cognitive trainingExperimental treatment 1 intervention
Group B: Conventional Exercise TrainingActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
d2 Test of Attention
A widely used neuropsychological test evaluating visual attention and processing speed. Participants are asked to quickly and accurately mark target symbols (e.g., the letter "d" with two dashes) among distractors on a sheet consisting of similar letters and symbols.
Time frame
From enrollment to the end of treatment at 8 weeks2
Trail Making Test Part A (TMT-A)
Assesses visual attention, processing speed, and psychological flexibility. The participant is required to connect numbered circles from 1 to 25 in order as quickly as possible.
Time frame
From enrollment to the end of treatment at 8 weeks3
Stroop Test
Stroop Test: Evaluates executive functions and attentional control. The participant must state the ink color of a word rather than reading the written word itself (e.g., the word "Blue" written in red ink should be answered as "red")
Time frame
From enrollment to the end of treatment at 8 weeks4
Trail Making Test Part B (TMT-B):
Trail Making Test Part B (TMT-B): Used to assess executive functions, cognitive flexibility, and attention. The participant alternates between numbers and letters in sequence (1-A-2-B-3-C…)
Time frame
From enrollment to the end of treatment at 8 weeksSecondary outcomes
1
Symbol Digit Modalities Test (SDMT)
Symbol Digit Modalities Test (SDMT): Measures processing speed and attention. Participants are presented with a key of symbol-digit pairings and asked to match as many symbols with their corresponding digits as possible within a set time
Time frame
From enrollment to the end of treatment at 8 weeks2
Functional Near-Infrared Spectroscopy (fNIRS)
Functional Near-Infrared Spectroscopy (fNIRS): A non-invasive method to measure prefrontal cortex activation by monitoring oxygenated and deoxygenated hemoglobin levels
Time frame
From enrollment to the end of treatment at 8 weeks3
Disability Assessment for Dementia (DAD)
Disability Assessment for Dementia (DAD): Developed to assess independence in activities of daily living among individuals with dementia. It evaluates both basic and instrumental activities of daily living, including self-care and social functioning
Time frame
From enrollment to the end of treatment at 8 weeks4
Dual Task Protocol
Dual Task Protocol: Participants will perform physical and cognitive tasks simultaneously. For example, during walking, they will be asked to complete word generation, simple arithmetic, or other attention-demanding tasks
Time frame
From enrollment to the end of treatment at 8 weeksLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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