The Effect of Exercise Training on lncRNA Expression in Rheumatoid Arthritis

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorSaglik Bilimleri Universitesi

About this trial

The goal of this observational study is to examine the effects of traditional respiratory rehabilitation and respiratory muscle strengthening training added to this program at the genetic level in in patients with rheumatoid arthritis-associated interstitial lung disease. The main questions it aims to answer are:

* Does respiratory muscle strengthening exercise added to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have additional benefits on rehabilitation outcome measures such as exercise capacity, shortness of breath, and muscle strength? * Does the gain obtained with respiratory muscle strengthening iin patients with rheumatoid arthritis-associated interstitial lung disease increase the quality of life of patients and have a positive effect on their psychological state? * Does respiratory rehabilitation applied to iin patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes? * Does respiratory muscle strengthening training applied in addition to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes? * Participants will be included in two different respiratory rehabilitation programs with and without respiratory muscle training, and pre- and post- treatment rehabilitation criteria and genetic changes will be compared.

Eligibility criteria

Qualifiers

Diagnosed with RA according to the ACR/EULAR 2010 classification criteria

Duration of diagnosis greater than 2 years

Disease activity with a DAS28 score below 5.1

Voluntary participation in the study

Disqualifiers

Having orthopedic deformities that may affect the treatment program

Pregnancy

Uncontrolled diabetes or heart disease

Participation in a rehabilitation program within the last 6 months

Trial design

Treatments tested in this trial

  • Standard pulmonary rehabilitation programme
  • Resistive threshold inspiratory muscle training
  • No intervention

Treatment groups

39 Participants
are divided into 3 treatment groups

Sponsors and collaborators