About this trial
For gynecologists, reaching a conclusion about the efficacy of intramyometrial Terlipressin injection versus intramyometrial Carbetocin injection on hemoglobin level and decreasing blood loss in women undergoing open myomectomy that would influence the clinical decision and best practice. Besides enriching the clinical evidence in open myomectomy without using haemostatic tourniquets. For society, our conclusion and recommendation shall maximize the benefits and managing the benefits of the technique used. Moreover, providing more information for women undergoing open myomectomy without using haemostatic tourniquets.
Eligibility criteria
Qualifiers
Women aged 16-45 yearsAppropriate medical status for open surgery (Largest Myoma size from 4 cm up to 20 cm)
Baseline hemoglobin ≥9 g/dl
No contra-indications to the use of glyopressin or carbitocin
Myoma-related symptoms, such as pelvic pressure or pain,menorrhagia, or infertility
Disqualifiers
Open myomectomy using mechanical tourniquet
Previous myomectomy
History of bleeding disorders
Concurrent anticoagulation therapy
Trial design
Treatments tested in this trial
- Terlipressin
- Carbetocin
- Saline