This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old. In the study group, patients will receive melatonin supplementation for at least two months prior to their IVF cycles. Cumulus cells will be collected after oocyte retrieval, and IVF outcomes will be assessed.
Age 35-45 years
BMI 18-30 kg/m2
planning to undergo IVF cycles
Primary ovarian insufficiency
history of oophorectomy
receiving oocyte donation
Chromosome anomaly