The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who had a stroke. Researchers want to understand how this device can help stroke patients use their hands better.
Age >=21 years old of any race or gender
First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 3 months from stroke onset
Unilateral arm weakness measured by FM-UM scale <= 62 out of 66
Inducible rest motor threshold and testing motor threshold recorded from the affected first dorsal interosseous (FDI) muscle from the study subject
Bilateral strokes (infarcts and/or hematoma)
Other co-existent neuromuscular disorders affecting upper extremity motor impairment.
History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study.
Uncontrolled hypertension despite medical treatment(s) at the time of randomization, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and randomized later).