The Effect of Pulse Field Ablation on Atrial Mechanics in Catheter Ablation of Paroxysmal Atrial Fibrillation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAssistance Publique - Hôpitaux de Paris

About this trial

The goal of this clinical trial is to compare the effect of pulmonary vein isolation on atrial function between pulse-field and cryoablation in patients over the age of 18 with paroxysmal atrial fibrillation. The main question it aims to answer is:

• Is catheter ablation energy (pulse field ablation) revealing a better preservation of the atrial function architecture than with conventional catheter ablation technologies ?

Participants will performed 2 IRMs with injection and completed Quality of Life Questionnaires. They participate in the study for 4 months.

Researchers will compare 2 arms:

* Pulse-Field Ablation * Cryoablation

Eligibility criteria

Qualifiers

Patient age ≥ 18

Established diagnosis of paroxysmal fibrillation, with a I/IIa/IIb indication for catheter ablation (ESC 2020 guidelines)

Episode of AF documented by ECG within the last 12 months

Patient able to give written informed consent

Disqualifiers

Non-paroxysmal atrial fibrillation

Contraindication to oral anticoagulation

Intracardiac thrombus

Previous ablation in the left atrium

Trial design

Treatments tested in this trial

  • Pulmonary vein isolation by pulse field ablation
  • Pulmonary vein isolation by cryoablation

Treatment groups

80 Participants
are divided into 2 treatment groups