About this trial
The study aims to assess the effect of superselective adrenal arterial embolization on vascular endothelial function in patients with primary aldosteronism based on brachial artery flow-mediated relaxation
Eligibility criteria
Qualifiers
(1)Aged 18-75 years, males and females;
(2)Blood pressure ≥ 140/90 mmHg on at least three non-same-day office visits without antihypertensive medication or 24-hour ambulatory blood pressure averaging >130/80 mmHg throughout the day or averaging >135/85 mmHg during the day;
(3)Primary aldosteronism was diagnosed in accordance with the 2016 international society of Endocrinology clinical guidelines after strict drug elution;
(4)Contraindications to spironolactone-free administration;
Disqualifiers
(1)Secondary hypertension of other causes;
(2)Pregnant women or those who have a fertility plan in the next year;
(3)Glomerular filtration rate EGFR < 45 ml/min/1.73m²;
(4)History of severe contrast allergy;
Trial design
Treatments tested in this trial
- Super selective adrenal artery embolization
- Spironolactone