The Effect of SAAE on Vascular Endothelial Function in PA Patients

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorSecond Affiliated Hospital of Nanchang University

About this trial

The study aims to assess the effect of superselective adrenal arterial embolization on vascular endothelial function in patients with primary aldosteronism based on brachial artery flow-mediated relaxation

Eligibility criteria

Qualifiers

(1)Aged 18-75 years, males and females;

(2)Blood pressure ≥ 140/90 mmHg on at least three non-same-day office visits without antihypertensive medication or 24-hour ambulatory blood pressure averaging >130/80 mmHg throughout the day or averaging >135/85 mmHg during the day;

(3)Primary aldosteronism was diagnosed in accordance with the 2016 international society of Endocrinology clinical guidelines after strict drug elution;

(4)Contraindications to spironolactone-free administration;

Disqualifiers

(1)Secondary hypertension of other causes;

(2)Pregnant women or those who have a fertility plan in the next year;

(3)Glomerular filtration rate EGFR < 45 ml/min/1.73m²;

(4)History of severe contrast allergy;

Trial design

Treatments tested in this trial

  • Super selective adrenal artery embolization
  • Spironolactone

Treatment groups

200 Participants
are divided into 2 treatment groups