About this trial
The primary objective of this study is to investigate the effect of short-term bed rest (4 hours) on heart function, measured by cardiac magnetic resonance (CMR), in healthy participants. This aim will be addressed through a single-arm repeated study, assessing participants during three hours of bedrest.
The hypothesis is that short-term bed rest will decrease cardiac output measured by repeated CMR scans.
This study will also investigate the reproducibility of CMR within a narrow time frame. Limited data are available on these aspects, despite their critical importance for conducting consecutive examinations, both in clinical practice and research trials10-12. The study also aims to investigate the appliances of short-time measures of cardiac function.
Eligibility criteria
Qualifiers
Age between 18-80 years old.
No use of medications with influence on heart function.
For ethical reasons, we only include participants who are willing to be informed on new health information, as CMR may reveal relevant secondary health findings.
Disqualifiers
Diabetes, kidney, or liver disease.
Contraindications to CMR, e.g., abdominal height exceed limitations of the MR-scanner, pacemaker, aortastent, neurostimulator, or other electronic device implanted, implanted metal devices, severe claustrophobia, or physiological diseases.
Pregnant, lactating, or planning to become pregnant within the study period.
In ongoing cancer treatment.
Trial design
Treatments tested in this trial
- Bedrest