To research and explore the antibody protection and immune memory after vaccination in children with KHE during sirolimus administration. To explore the feasibility (safety and efficacy) of vaccination in a timely manner during the administration of sirolimus in children with KHE. To search for back-up plans for vaccination regimens for KHE patients taking sirolimus in children who do not respond to primary vaccination.
KHE patients treated with sirolimus.
After immunoglobulin and flow cytometry assays, as well as outpatient evaluation and assessment, those participants will be vaccinated with live attenuated vaccines or inactivated vaccines in a timely order according to the advice.
Healthy children with no immune deficiencies.
Participants are vaccinated according to the National Immunization Program in a timely manner.
HBsAg, HBeAg positive, or other active infectious diseases;
History of immunodeficiency or low immunoglobulin levels;
Autoimmune disease or fever during blood collection;
Use of other medication or surgery;