This study aims to investigate shorter vs. standard filter lifespans in critically ill patients receiving continuous renal replacement therapy (CRRT) for acute kidney injury (AKI). The aim of this trial is to reliably implement,scheduled filter changes and to investigate whether shorter filter lifetime is associated with a lower incidence in rate of new infections.
Adult ≥ 18 years
Critically ill patients with severe AKI consistent with KDIGO stage 3 and an absolute indication for CRRT
Written consent form from the patient or legal representative or authorized representative or emergency inclusion
End-stage kidney disease or chronic dialysis dependence
Chronic kidney disease with eGFR<20ml/min/1.73 m²
Prior kidney transplant
Prior renal replacement therapy during the index admission before randomization