A multicentre cross-sectional cohort study to assess the difference in bioprosthetic micro-calcification activity, detected with 18F-NaF PET-CT, as early marker of transcatheter valve degeneration, between patients with vs. without subclinical leaflet thrombosis at five years after TAVI; and between patients with intra-annular vs. supra-annular TAVI prostheses.
Successful TAVI with Sapien or CoreValve Evolut prosthesis about 5 years ago
Able to undergo hybrid 18F-NaF PET-CT imaging and transthoracic echocardiography
Written informed consent
Temporary or chronic oral anticoagulation use after TAVI
Known severe renal insufficiency
Known severe paravalvular regurgitation
History of valve-in-valve procedure