This study will investigate the effect of providing a daily ketogenic nutritional supplement in the evening for a prolonged time (4 weeks) to induce a mild ketogenic state during the night in healthy elderly (60-80 years), overweight/obese (BMI: 25-35 kg/m2) individuals with low physical activity, on 24h rhythmicity in energy metabolism as compared to a non-ketogenic, isocaloric control.
Aged 60-80 years
Body mass index (BMI) 25-35 kg/m2
Sedentary lifestyle (not more than 2 hours of structured physical activity per week in the past 3 months)
Stable dietary habits (no weight loss or gain > 5 kg in the past 3 months)
Type 2 diabetes
Participants with active congestive heart failure and/or severe renal and or liver insufficiency
Uncontrolled hypertension
Alcohol consumption of >3 servings per day for men and >2 servings per day for women