This study will evalute the effect of a low glycemic load (LGL diet on dysglycemia, insulin requirements, DXA-derived body composition, gastrointestinal symptoms and quality of life measures in adults with cystic fibrosis-related diabetes (CFRD). We will use continuous glucose monitors (CGM) to assess the LGL diet both in a controlled setting (via a meal delivery company) and in free-living conditions.
18 years and above
Genetically confirmed diagnosis of CF
Diagnosis of pancreatic insufficiency, requiring pancreatic enzyme replacement
FEV1 <50% predicted on most recent pulmonary function testing
BMI <18 kg/m2
Currently receiving enteral nutrition support via GT feeds
Pregnancy, plan to become pregnant in the next 3-months, or sexually active without use of contraception
Rhode Island Hospital
Lead sponsor
Cystic Fibrosis Foundation
Collaborator